First report and characterization of peste des petits ruminants virus in Liberia, West Africa

First report and characterization of peste des petits ruminants virus in Liberia, West Africa

Peste des petits ruminants (PPR), is a contagious and often fatal disease affecting sheep and goats that is currently endemic in Africa, the Middle East, the Indian subcontinent and China. Understanding the molecular epidemiology and evolution of PPR virus (PPRV) can assist in the control of the transboundary spread of this economically important disease. Here we report the isolation of a PPRV from pathological and swab samples collected from goats in Liberia, West Africa in July 2015.

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Rinderpest Experience

Rinderpest Experience

Rinderpest, the most dreaded disease of cattle, originated as far back as the  domestication of cattle, occurring in Asia more than 10,000 years ago. It has been the main preoccupation of Veterinary Service activities for many centuries and was the major motivation for establishing the first veterinary school in Lyon, France, in 1761. Gaining control of the disease was the impetus for the founding of many regional and international organizations (including the World Organization for Animal Health) .

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Specific Detection of Peste des Petits Ruminants Virus

Specific Detection of Peste des Petits Ruminants Virus

Peste des petits ruminants (PPR), The causal agent is peste des petits ruminants virus (PPRV), which belongs to the genus Morbillivirus in the family Paramyxoviridae. This genus also includes measles virus  (MV), canine distemper virus (CDV) and rinderpest virus (RPV). All are closely related viruses with serological cross reactivity. In this study, we have developed a Luciferase Immunoprecipitation System (LIPS) for the rapid detection of antibodies against PPRV in serum samples and for specific differentiation from antibodies against RPV.

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Xerovac: an ultra rapid method for the dehydration and preservation of live attenuated Rinderpest and Peste des Petits ruminants vaccines

Xerovac: an ultra rapid method for the dehydration and preservation of live attenuated Rinderpest and Peste des Petits ruminants vaccines

The accepted procedure for the long-term preservation of live viruses and bacteria in vaccines has been lyophilisation. We show that thermolabile viruses can be dehydrated in vitro, within 18 h, in an excipient containing trehalose. We further demonstrate that in the resulting dehydrated state, where the viruses are captive in a metastable glass  composed of trehalose, they are capable of resisting 45°C for a period of 14 days with  minimal loss of potency.

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